Ethyl pyruvate reduces liver injury at early phase but impairs regeneration at late phase in acetaminophen overdose
نویسندگان
چکیده
منابع مشابه
Ethyl pyruvate reduces liver injury at early phase but impairs regeneration at late phase in acetaminophen overdose
INTRODUCTION Inflammation may critically affect mechanisms of liver injury in acetaminophen (APAP) hepatotoxicity. Kupffer cells (KC) play important roles in inflammation, and KC depletion confers protection at early time points after APAP treatment but can lead to more severe injury at a later time point. It is possible that some inflammatory factors might contribute to liver damage at an earl...
متن کاملAcetaminophen Overdose and Drug-Induced Liver Injury
The advances in modern medicine have brought about a lot of changes in how we deal with illnesses. One of these relatively new found technologies is the use of medications. However, this has led many to assume that all of the diseases suffered can be treated with medications alone. The danger is more prominent among those who take these without the consultation of health care providers. A poor ...
متن کاملclimate change in gavkhouni basin at the late quaternary phase
introduction in spite of its short time period compared with the earth long evolution history, quaternary has had a significant effect on the final formation of the landforms and vital resources. it is the final analysis of these levels and fully dependent on the earth genetic diseases and, above all, significant climate changes that have happened during this period. gavkhouni basin morphologic...
متن کاملclimate change in gavkhouni basin at the late quaternary phase*
introduction in spite of its short time period compared to the earth evolution history and formation, quaternary has had a significant effect on the final formation of the land form and vital resources. it is the final analysis of these levels and fully dependent sources to the earth genetic diseases and, above all, significant climate changes that have happened during this period; gavkhouni ba...
متن کاملMathematical modeling of liver injury and dysfunction after acetaminophen overdose: early discrimination between survival and death.
UNLABELLED Acetaminophen (APAP) is the leading cause of acute liver injury in the developed world. Timely administration of N-acetylcysteine (N-Ac) prevents the progression of serious liver injury and disease, whereas failure to administer N-Ac within a critical time frame allows disease progression and in the most severe cases may result in liver failure or death. In this situation, liver tran...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Critical Care
سال: 2012
ISSN: 1364-8535
DOI: 10.1186/cc11149